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MODS is a medical condition of acute multi-organ failure as a result of various insults. It is often seen in surgical patients. However, MODS is rarely associated with minor, surgical procedures, such as splenectomy. The pathogenetic mechanism of MODS after splenectomy is considered to be a combination of mechanical circulation disturbance with hyperdynamic circulation, an inflammatory reaction secondary to increased splenic tissue, and bacterial overgrowth. This patient probably had mild MODS which was overlooked during the operation. To prevent MODS after splenectomy, assessment of both the hemodynamic status and function of the spleen must be made preoperatively.Cytotoxic, Antiviral and Antimicrobial Agents from Liquid and Solid Culture of Aspergillus cremeus. 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